Pioneering meiotic recombination
نویسندگان
چکیده
منابع مشابه
Meiotic recombination heats up.
Meiotic recombination is essential for the production of viable haploid gametes in sexually-reproducing organisms, and creates new allelic combinations, whichmay facilitate evolution by natural selection and genetic drift (Barton & Charlesworth, 1998). Crossovers between homologous chromosomes establish physical connections (chiasmata) which enable proper chromosome segregation. In the absence ...
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Studies of human trisomies indicate a remarkable relationship between abnormal meiotic recombination and subsequent nondisjunction at maternal meiosis I or II. Specifically, failure to recombine or recombination events located either too near to or too far from the centromere have been linked to the origin of human trisomies. It should be possible to identify these abnormal crossover configurat...
متن کاملMeiotic recombination hotspots in plants.
Many studies have demonstrated that the distribution of meiotic crossover events along chromosomes is non-random in plants and other species with sexual reproduction. Large differences in recombination frequencies appear at several scales. On a large scale, regions of high and low rates of crossover have been found to alternate along the chromosomes in all plant species studied. High crossover ...
متن کاملDistribution of meiotic recombination sites.
Meiotic recombination generates gene conversion and crossover events that are distributed heterogeneously in the genome. Studies in yeast show that initiation of recombination, which occurs by the formation of DNA double-strand breaks, determines the distribution of gene conversion and crossover events that take place in nearby intervals. Recent data in humans and mice also indicate the presenc...
متن کاملTargeted Stimulation of Meiotic Recombination
Meiotic recombination in Saccharomyces cerevisiae is initiated by programmed DNA double-strand breaks (DSBs), a process that requires the Spo11 protein. DSBs usually occur in intergenic regions that display open chromatin accessibility, but other determinants that control their frequencies and non-random chromosomal distribution remain obscure. We report that a Spo11 construct bearing the Gal4 ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2020
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.336438.120